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550 5.7.750 Service unavailable. Client blocked from sending from unregistered domains

Provider: Microsoft 365 / Outlook

Sample bounce line

550 5.7.750 Service unavailable. Client blocked from sending from unregistered domains

What it means

Exchange Online is blocking the tenant because a suspicious number of messages are being sent from domains that aren't provisioned (aren't accepted domains) in the tenant.

Why it happens

How to fix it

  1. Only an email admin in the organization can fix this.
  2. Add and validate all domains you use to send email in Microsoft 365 (the most common fix).
  3. Use a certificate-based outbound connector whose certificate domain is an accepted and validated domain.
  4. Look for unusual connectors and compromised accounts, and validate connectors.
  5. After fixing the underlying cause, contact Microsoft Support to have the block removed.

DNS record examples (replace example.com and the values with your own):

example.com.  IN  TXT  "v=spf1 include:_spf.your-mail-provider.example ~all"   ; one SPF record per domain; use your provider's real include value

Check your domain now

Many of these errors come from missing or broken SPF, DKIM, DMARC or reverse DNS records. Enter your domain to run the free check.

Check your domain now

Related errors

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Official documentation

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